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Pragmatic trials are those that are designed to provide information for the practice of clinical trials in real life. They are often focused on practical aspects of the research design, like the recruitment and consent process in adherence, as well as the use of routinely available equipment.
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A pragmatic study that involves different investigators and participants from various geographical regions is the Home Blood Pressure Management study (HBPM). This kind of heterogeneity, that is crucial for pragmatic trials to be reliable and lessen the chance of bias is also essential. However excessive heterogeneity could cause issues with the design of the trial.
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Pragmatic trials aim to mimic real-life situations and attain maximum external validity. Usually, they are ordered by policymakers and practitioners in order to inform their decisions. They are also a good method of determining the cause-effect relationship between an intervention and its outcomes. However, they should not, be used to replace explanatory studies.
The pragmatism concept is controversial and there are doubts about whether pragmatic trials should replace or complement them. Schwartz and Lellouch1 proposed a distinction between explanatory studies, which confirm a physiological hypothesis or clinical hypothesis, and pragmatic trials that aid in the decision-making process for policy and practice. They also proposed the framework for pragmatic trials, dubbed PRECIS.2 This tool was designed to define the characteristics of a pragmatic study, including recruitment, design and 프라그마틱 무료 슬롯 delivery of the intervention, and monitoring.
The number of pragmatic trials is increasing. A recent Medline query using the keywords naturalistic and pragmatic, restricted to randomised controlled trials (RCTs), returned 34 articles. They are displayed in red on Figure 2. This suggests that the health sciences community has become more aware of the importance of pragmatic thinking. However, it is important to remember that the majority of these studies were conducted in primary care settings.
